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In addition, the AST and ALT values of the untreated control group were also significantly higher than that of the uninfected group. However, after the treatment with MBZ-OS or MBZ-1 tragacanth, the values of these two parameters (AST and ALT) were decreased and reached to the level of the uninfected control. Then the optimal MBZ oily suspension was chosen by comparing the pharmacokinetic parameters, especially the values of C max and AUC 0-t (unpublished).
However, the lower dosage used in this study made it possible to reduce the oral dose of MBZ-OS in the future clinical trials. With such long term chemotherapy, the patients hardly continue the treatment as they are more likely to comply with ABZ because it is more cost-effective and involves fewer tablets.